Research Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS
Principal Investigator, NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI)
In Young has received her Ph.D in the field of cancer biology and therapeutics from University of Auckland. Since then, she has expanded her research interest to Synthetic Biology by joining the Chang lab in 2012. She has made contributions in enabling various programmable functionalities in microbes to execute the pathogen detection-mediated pathogen killing activity. Her research was published in ACS synthetic biology and Nature Communications, as well as being notably mentioned in various media including Nature and The Economist. She serves as a reviewer for international journals such as Biotechnology journal, Chemical Engineering Science and 3Biotech. Her current research focuses on in-depth study and modulation of the gut microbiome and its various physiological axis for human health and therapy.
Reprogramming probiotics and commensal microbes for therapy.
Antimicrobial resistance and infectious pathogens.
Understanding the role of microbiome in human diseases.
Mammalian cell engineering for bioproduction.
Development of biosensors and genetic tool-box in probiotics.
- Hwang I.Y., Chang M.W (2020) Engineering commensal bacteria to rewire host-microbiome interactions, Curr Opin Biotechnol. 62, 116-122.
- Lubkowicz, D., Ho, C. L., Hwang, I. Y., Yew, W. S., Lee, Y. S., and Chang, M. W. (2018) Reprogramming Probiotic Lactobacillus reuteri as a Biosensor for Staphylococcus aureus Derived AIP-I Detection, ACS Synth Biol 7, 1229-1237.
- Hwang, I. Y., Koh, E., Wong, A., March, J. C., Bentley, W. E., Lee, Y. S., and Chang, M. W. (2017) Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models, Nat Commun 8, 15028.*
- Hwang, I. Y., Koh, E., Kim, H. R., Yew, W. S., and Chang, M. W. (2016) Reprogrammable microbial cell-based therapeutics against antibiotic-resistant bacteria, Drug Resist Updat. 27, 59-71.
- Hwang, I. Y., Tan, M. H., Koh, E., Ho, C. L., Poh, C. L., and Chang, M. W. (2014) Reprogramming microbes to be pathogen-seeking killers, ACS Synth Biol 3, 228-237.*