Dr Maybelle Darlene Kho GOResearch Assistant Professor


Research Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS
Research Cluster Lead, Wilmar-NUS Corporate Laboratory ([email protected])
Principal Investigator, NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI)


Maybelle GO received her PhD in Chemistry from University at Buffalo, State University of New York in 2009 under the supervision of John P. Richard.  She joined Associate Professor Wen Shan Yew’s group at National University of Singapore as a research fellow right after her graduation. Her interests and domain expertise include characterization of enzyme mechanisms. Her contributions in enzyme engineering includes characterization of various enzymes and understanding their functional mechanisms which could translate towards drug discovery, green chemistry, and synthetic biology applications.

Research Interest

Characterization of enzymes for therapeutic and commercial applications.

Selected Publications

  1. Yew WS, Liow LT, Go M (2019) Characterization of Constitutive Promoters from the Anderson library in Chromobacterium violaceum ATCC 12472. Engineering Biology. 3 (3): 57-66
  2. Yew WS, Rajasabhai R, Go M (2019) Characterization of the Bacterial Biosensor GMG in coli BL21 (DE3). Engineering Biology. 3 (3): 46-56
  3. Lim YP, Go MK, Raida M, Inoue T, Wenk MR, Keasling JD, Chang MW, Yew WS (2018) Synthetic Enzymology and the Fountain of Youth: Repurposing Biology for Longevity. ACS Omega. 3 (9):11050-11061
  4. Go MK, Chow JY, Yew WS. Directed Evolution of Quorum-Quenching Enzymes: A Method for the Construction of a Directed Evolution Platform and Characterization of a Quorum-Quenching Lactonase from Geobacillus kaustophilus (2018) In Quorum Sensing: Methods and Protocols, Leoni, L.; Rampioni, G., Eds. Springer New York: New York, NY, pp 311-323
  5. Go MK, Wongsantichon J, Cheung VWN, Chow JY, Robinson RC, Yew WS. Synthetic Polyketide Enzymology: A Platform for Biosynthesis of Novel Anti-Microbial Polyketides (2015) ACS Catalysis. 5 (7): 4033-4042