Ee Lui ANG
Ee Lui ANGAdjunct Associate Professor
ang_ee_lui@ a-star.edu.sg

Office Location – Singapore Institute of Food and Biotechnology, 31 Biopolis Way, #02-01 Nanos, Singapore 138669

Affiliations

Department Co-Head (Biotransformation and Engineering), A*STAR SIFBI
Adjunct Associate Professor, NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI)

Biography

Ee Lui Ang received his joint PhD degree in Chemical and Biomolecular Engineering from the University of Illinois at Urbana-Champaign and the National University of Singapore in 2007. He then joined Codexis Laboratories Singapore, where he held the positions of Project Technical Lead, Molecular and Cellular Biology Team Leader, and Project Manager for a bioindustrial project. Ang joined A*STAR’s then-Institute of Chemical and Engineering Sciences (ICES) in 2012 as a Team Leader of the Metabolic Engineering Research Lab, and subsequently A*STAR’s Singapore Institute of Food and Biotechnology Innovation (SIFBI) in 2020 as a Team Leader in the Discovery and Transformation division. He currently leads SIFBI’s Strain Engineering Group. His research interests are in developing metabolic engineering and synthetic biology tools and strategies to engineer proteins, pathways and genomes for advanced biomanufacturing.

Professional Appointments

Editorial Advisory Board for ACS Catalysis
Editorial Advisory Board for ACS Synthetic Biology

Education

2007 – PhD (Chemical Engineering), University of Illinois at Urbana-Champaign & National University of Singapore
2002 – B. Eng. (Chemical Engineering), National University of Singapore

Research Interest

Uncovering the potential of biological systems and translating these insights into solutions for advanced biomanufacturing.

Current Research Projects

Establishing sustainable biomanufacturing platforms for high value compounds using renewable C1 feedstocks
Development of machine learning-enhanced workflows to accelerate enzyme engineering and expand biosynthetic repertoires of challenging enzymes
Exploration of functional proteins for nutrition and development of precision fermentation platforms for their production

Selected Publications

  1. Z. Liu, Y.S. Law, R.K. Verma, Y.L. Goh, M.F.E. Wong, B. Sana, H. Fan*, E.L. Ang*, Y.H. Lim*, A Mn(salen)-Based Artificial Metalloenzyme for Nitrene and Oxene Transfer Catalysis, 2025, ChemBioChem, 26 (5), e202400774.
  2. R.K. Verma, W.L. Yeo, E. Tiong, E.L. Ang*, Y.H. Lim*, F.T. Wong*, H. Fan*, Unveiling the molecular basis of selective fluorination of SAM-dependent fluorinases, Chemical Science, 2025, 16, 10610. DOI: 10.1039/D5SC00081E.
  3. N.V.M.A. Muthaliff, Y.Z. Ng, W.M. Guo, E.L. Ang, Saccharomyces cerevisiae whole cell biotransformation for the production of aldehyde flavors and fragrances, 2024, Appl Microbiol Biotechnol, 108, 500.
  4. Y.S. Law, N.A. Muthaliff, Y. Wei, F. Lin, H. Zhao, E.L. Ang, Biochemical Investigation and Engineering of a Tardigrade X Family DNA Polymerase for Template-Independent DNA Synthesis, 2024, ACS Catalysis, 14 (16), 12318-12330
  5. E. Klumbys, W. Xu, L. Koduru, E. Heng, Y. Wei, F.T. Wong, H. Zhao*, E.L. Ang*, Discovery, characterization, and engineering of an advantageous Streptomyces host for heterologous expression of natural product biosynthetic gene clusters, 2024, Microb Cell Fact, 23, 149.
  6. G.R. Peh, T. Tay, L.L. Tan, E. Tiong, J. Bi, Y.L. Goh, S. Ye, F. Lin, C.J.X. Tan, Y.Z. Tan, J. Wong, H. Zhao, F.T. Wong*, E.L. Ang* and Y.H. Lim*, Site-selective chlorination of pyrrolic heterocycles by flavin dependent enzyme PrnC, 2024, Commun Chem, 7, 7.
  7. W. L. Yeo, D. W. P. Tay, J. M.T. Miyajima, S. Supekar, T. M. Teh, J. Xu, Y. L. Tan, J. Y. See, H. Fan, S. Maurer-Stroh*, Y. H. Lim*, and E. L. Ang*, Directed Evolution and Computational Modeling of Galactose Oxidase toward Bulky Benzylic and Alkyl Secondary Alcohols, 2023, ACS Catalysis, 13 (24), 16088-16096.
  8. G.R. Peh, G.A. Gunawan, T. Tay, E. Tiong, L.L. Tan, S. Jiang, Y.L. Goh, S. Ye, J. Wong, C.J. Brown, H. Zhao, E.L. Ang*, F.T. Wong*, Y.H. Lim*, Further Characterization of Fungal Halogenase RadH and Its Homologs, 2023, Biomolecules, 13 (7), 1081
  9. J. Liang, H. Zhang, Y.L. Tan, H. Zhao, and E.L. Ang, Directed Evolution of Replication-Competent Double-Stranded DNA Bacteriophage toward New Host Specificity, 2022, ACS Synthetic Biology, 11 (2), p634-643.
  10. H. Sun, H. Zhao, and E.L. Ang, A New Biosensor for Stilbenes and a Cannabinoid Enabled by Genome Mining of a Transcriptional Regulator, 2020, ACS Synthetic Biology, DOI: 10.1021/acssynbio.9b00443.

* Corresponding author; # Co-first author