Jin-Soo KIM
Jin-Soo KIMToh Chin Chye Visiting Professor
[email protected]

Affiliations

School of Engineering Biology, KAIST

Biography

Jin-Soo Kim is an entrepreneur and chemist-turned-biologist. In 1999, he founded ToolGen, Inc., a startup focused on gene regulation and genome editing. In 2022, he established Edgene, Inc. and GreenGene, Inc, specializing in therapeutic mitochondrial DNA editing for the treatment of mitochondrial genetic disorders and chloroplast DNA editing to enhance the efficiency of photosynthesis in plants, respectively. He also served as professor at Seoul National University until 2016 and Director at Institute for Basic Science until 2022. He is now a professor at Korea Advanced Institute for Science and Technology (KAIST) and a visiting professor at National University of Singapore.

Education

2012 Ph.D. in Microbiology, Indiana University Bloomington
2006 M. Phil. in Biology, the Chinese University of Hong Kong
2004 B.Sc. in Molecular Biotechnology, the Chinese University of Hong Kong
2004 BBA minor in Integrated BBA program, the Chinese University of Hong Kong

Research Interest

Genome engineering with programmable nucleases and deaminases including CRISPR systems
Nuclear and organellar genome editing in plants and animals
Gene and cell therapy using programmable nucleases and deaminases

Current Research Projects

Therapeutic mitochondrial DNA editing in vitro and in vivo
Chloroplast gene editing for enhancing the photosynthetic efficiency in plants

Selected Publications

  1. Engineering TALE-linked deaminases to facilitate precision base editing in mitochondrial DNA. Cell (2024).
  2. Base editing of organellar DNA with programmable deaminases. Nat. Rev. Mol. Cell Biol. (2023).
  3. Precision mitochondrial DNA editing with high-fidelity DddA-derived base editors. Nat. Biotechnol.(2023).
  4. Targeted A-to-G base editing in human mitochondrial DNA with programmable deaminases. Cell (2022).
  5. Chloroplast and mitochondrial DNA editing in plants. Nature Plants (2021).
  6. Genome-wide target specificity of CRISPR RNA-guided adenine base editors. Nat. Biotechnol. 37, 430 (2019).
  7. Correction of a pathogenic gene mutation in human embryos. Nature 548, 413 (2017).
  8. Genome-wide analysis reveals specificities of Cpf1 endonucleases. Nat. Biotechnol. 34, 863 (2016).
  9. Digenome-seq: Genome-wide profiling of CRISPR-Cas9 off-target effects. Nature Methods 12, 237 (2015).
  10. Targeted genome engineering in human cells with Cas9 RNA-guided endonuclease. Nat. Biotechnol. (2013).

* Corresponding author; # Co-first author