Biologics are broad range of complex biomolecules that are produced in a living system such as a microorganism, or plant or mammalian cells, often through recombinant DNA technology. Most common examples of biologics include monoclonal antibodies, Insulin and Botox, which are used to to prevent, treat, and cure rare diseases. Chinese hamster ovary (CHO) cells are the most widely used mammalian cell lines for therapeutic recombinant proteins production. However, tedious process and suboptimal productivity limits the wide application of CHO-mediated bioproduction. At SynCTI, we use high end genome editing technology and synthetic gene circuits to develop and improvise CHO based expression system so that this platform can be genetically modified in a reliable method to generate target biomolecules. The developed CHO cell lines feature site-specific integration and non-antibiotic based selection system to facilitate efficient stable cell line generation. Such a platform can further be employed for downstream industrial and research applications.
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