Dr Jiahai SHIAssistant Professor


Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS
Principle Investigator, NUS Medicine Synthetic Biology Translational Research Programme

Education and Research

  • Postdoctoral Fellow, Advisor: Dr. Harvey Lodish Whitehead Institute for Biomedical Research / Massachusetts Institute of Technology, Cambridge, MA, 2010 – 2015
  • Ph.D., Biochemistry and Biophysics, National University of Singapore, Singapore 2008
  • B.Sc., Biology, Xiamen University, P. R. China 2002

Professional Appointments

  • 2021 – Presence Assistant Professor, National University of Singapore
  • 2015 – 2021       Assistant/Associate Professor, City University of Hong Kong
  • 2010 – 2015       Postdoctoral Fellow, Whitehead Institute for Biomedical Research, MIT
  • 2008 – 2010       Research Fellow, National University of Singapore

Research Interest

  1. Mechanistic study of terminal erythropoiesis
  2. Gene therapy in hematopoietic stem cells against blood disorders and metabolic diseases

Selected Publications

  1. Dong H, Zhang Y, Wang J, Xiang H, Lv T, Wei L, Yang S, Liu X, Ren B, Zhang X, Liu L, Cao J, Wang M, Shi J#, Yang N#., “Cas9-Based Local Enrichment and Genomics Sequence Revision of Megabase-Sized Shark IgNAR Loci.”, J Immunol. 2022 Jan 1;208(1):181-189. doi: 10.4049/jimmunol.2100844., (#: co-corresponding author)
  2. Wei L, Wang M, Xiang H, Jiang Y, Gong J, Su D, Al Azad MAR, Dong H, Feng L, Wu J, Chan LL, Yang N#, Shi J#, “Bamboo Shark as a Small Animal Model for Single Domain Antibody Production.”, Front Bioeng Biotechnol. 2021 Dec 8;9:792111. doi: 10.3389/fbioe.2021.792111. (#: co-corresponding author)
  3. Panbing Wang, M. A. R. Al Azad, Xiong Yang, Paolo R. Martelli, Kam Yan Cheung, Jiahai Shi#, Yajing Shen#, “Self-adaptive and efficient propulsion of Ray sperms at different viscosities enabled by heterogeneous dual helixes.” Proc Natl Acad Sci U S A. 2021, accepted, (#: co-corresponding author)
  4. Pham TC, Jayasinghe MK, Pham TT, Yang Y, Wei L, Usman WM, Chen H, Pirisinu M, Gong J, Kim S, Peng B, Wang W, Chan C, Ma V, Nguyen NTH, Kappei D, Nguyen XH, Cho WC, Shi J#, Le MTN#, “Covalent conjugation of extracellular vesicles with peptides and nanobodies for targeted therapeutic delivery.” J Extracell Vesicles. 2021 Feb;10(4):e12057. doi: 10.1002/jev2.12057. Epub 2021 Feb 16. (#: co-corresponding author)
  5. Ru Zhen, Chingyee Moo, Zhenzhen Zhao, Mengying Chen, He Feng, Xiaojun Zheng, Liang Zhang, Jiahai Shi#, Caiyong Chen#, “Wdr26 regulates nuclear condensation in developing erythroblasts” Blood, 2020 Jan 16;135(3):208-219. doi: 10.1182/blood.2019002165 (#: co-corresponding author) (cover story)
  6. Yuanyan Tan, Athena H. Y. Chu, Siyu Bao, Duc Anh Hoang, Firaol Tamiru Kebede, Wenjun Xiong, Mingfang Ji, Jiahai Shi#, Zongli Zheng#, “Rationally engineered Staphylococcus aureus Cas9 nucleases with high genome-wide specificity”, Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):20969-20976. doi: 10.1073/pnas.1906843116. Epub 2019 Sep 30 (#: co-corresponding author)