Synthetic genomics, which is a major arm of synthetic biology, aims to create organisms harboring customized or tailor made chromosomal sequences carrying desired genetic codes that confer novel functionalities. Due to astounding advances made in DNA synthesis technologies, construction of designer synthetic genomes is becoming increasingly feasible, thus enabling deeper understanding of biological functions. At SynCTI, we are a part of the Synthetic Yeast 2.0 (Sc2.0) consortium working towards the construction of the first eukaryotic cell with a functional fully synthetic genome. A prominent feature of Sc2.0 is the incorporation of an in-built genome evolution system named SCRaMbLE that enables on-demand rearrangement of the synthetic genome. This platform allows generation of large mutant libraries that can be screened for strains of desired characteristics. Using this system, we aim to isolate and study a host of yeast variants to address fundamental biological questions along with developing novel biotechnological applications
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