Dr Albert Bo XUEResearch Assistant Professor


Research Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS
Research Cluster Lead, Wilmar-NUS Corporate Laboratory (Wil@NUS)
Principle Investigator, NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI)


XUE Bo obtained his Ph.D in Biochemical Engineering from Tianjin University, China, and received training on protein X‐ray crystallography at the Biomedical Centre of Uppsala University, Sweden. He has broad interests in both basic and applied research, and has made significant contributions to various projects on actin-binding proteins, self-assembling peptides and enzymes. His current research focuses on deciphering the structure-function relationship of novel enzymes, and on the application of these enzymes in synthetic biology. He received and participated in two competitive research programmes. He has published over 30 peer-reviewed articles. He serves as a reviewer for international journals such as Biotechnology for Biofuels, Applied Biochemistry and Biotechnology, & 3 Biotech.

Research Interest

Structure-guided protein engineering and rational design of enzymes.

Selected Publications

  1. Go M#, Zhao L#, Xue B#, Robinson RC, Fan H, Yew WS (2020) Directed computational evolution of quorum-quenching lactonases from the amidohydrolase superfamily. Structure, submitted.
  2. Szatmári D, Xue B, Kannan B, Burtnick LD, Bugyi B, Nyitrai M, Robinson RC (2018). ATP competes with PIP2 for binding to gelsolin. PLoS ONE 13, e0201826.
  3. Chan KH, Xue B, Robinson RC, Hauser CAE (2017). Systematic Moiety Variations of Ultrashort Peptides Produce Profound Effects on Self-Assembly, Nanostructure Formation, Hydrogelation, and Phase Transition. Scientific Reports 7, 12897.
  4. Sun H, Yeo WL, Lim YH, Chew X, Smith DJ, Xue B, et al. (2016) Directed evolution of a fluorinase for improved fluorination efficiency with a non-native substrate. Angew Chem Int Ed Engl 55, 14277–14280.
  5. Xue B*#, Leyrat C#, Grimes JM, Robinson RC (2014) Structural basis of thymosin- beta4/profilin exchange leading to actin filament polymerization. Proc Natl Acad Sci USA 111: E4596-4605.
  6. Chow JY#, Xue B#, Lee KH, Tung A, Wu L, et al. (2010) Directed evolution of a thermostable quorum-quenching lactonase from the amidohydrolase superfamily. J Biol Chem 285: 40911-40920.

* Corresponding author; # Co-first author